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KMID : 0363020090390000223
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Journal of Korean Academy of Periodontology
2009 Volume.39 No. 0 p.223 ~ p.230
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Bone regeneration capacity of two different macroporous biphasic calcium materials in rabbit calvarial defect
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Park Jung-Chul
Yun Jeong-Ho
Jung Ui-Won
Kim Chang-Sung
Choi Seong-Ho
Cho Kyoo-Sung
Kim Chong-Kwan
Lim Hyun-Chang
Sohn Joo-Yeon
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Abstract
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Purpose: Synthetic bone products such as biphasic calcium phosphate (BCP) are mixtures of hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP). In periodontal therapies and implant treatments, BCP provides to be a good bone reconstructive material since it has a similar chemical composition to biological bone apatites. The purpose of this study was to compare bone regeneration capacity of two commercially available BCP.
Methods: Calvarial defects were prepared in sixteen 9-20 months old New Zealand White male rabbits. BCP with HA and β-TCP (70:30) and BCP with Silicon-substituted hydroxyapatite (Si-HA) and β-TCP (60:40) particles were filled in each defect. Control defects were filled with only blood clots. Animals were sacrificed at 4 and 8 week postoperatively. Histomorphometric analysis was performed.
Results: BCP with HA and β-TCP 8 weeks group and BCP with Si-HA and β-TCP 4 and 8 weeks groups showed statistically significant in crease (P<0.05) in augmented area than control group. Newly formed bone area after 4 and 8 weeks was similar among all the groups. Residual materials were slightly more evident in BCP with HA and β-TCP 8 weeks group.
Conclusions: Based on histological results, BCP with HA and β-TCP and BCP with Si-HA and β-TCP appears to demonstrate acceptable space maintaining capacity and elicit significant new bone formation when compared to natural bone healing in 4 and 8 week periods.
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KEYWORD
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bone substitutes, hydroxyapatite wound healing
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